Dr. Alberto Caminero | McMaster University Research: The role of microbial metabolism in food intolerances associated with inflammatory bowel disease Date: 2021-2024 Amount: $375,000
Patients with inflammatory bowel disease (IBD) report a variety of food intolerances. However, the main dietary triggers and pathways involved are unknown. Certain foods such as wheat and dairy that are not properly digested by our enzymes may cause adverse effects. Although our gut microbiota may help in the digestion, IBD patients often present an altered microbiota, which may include the loss of beneficial microbes. Dr. Caminero’s study aims to broaden our understanding of whether the microbes hosted in the guts of IBD patients have a reduced digestive capacity against certain types of foods thus causing adverse effects. The study will also look into the effects of different dietary components in animal models of colitis. The findings of this study will help guide dietary advice in clinical practice; in particular, it will pave the way for novel preventive and therapeutic approaches using probiotics in IBD patients with specific food intolerances. To learn more about Dr. Caminero's research, watch the video below.
Dr. Jean-Eric Ghia | University of Manitoba Research: Function of follicular dendritic cell secreted protein in ulcerative colitis Date: 2021-2022 Amount: $50,000
People living with ulcerative colitis are known to have inflammation and imbalances of microbes in the gut. Dr. Ghia and his team aim to study the effects of a protein (follicular dendritic cell secreted protein) in regulating inflammation, the immune system and the gut microbes and their impact in the development of ulcerative colitis. To learn more about Dr. Ghia's research, watch the video below.