Participate in Research

Research studies help find new methods for diagnosing, treating, managing, and preventing Crohn's disease and ulcerative colitis. Even the most promising scientific findings must first be proven to be safe and effective before they can be used in the management of inflammatory bowel disease (IBD).

If you are interested in learning more about participating in a research study or clinical trial, speak with your doctor.

For Researchers recruiting patients for study participation

Are you a researcher looking to promote your research study among patients with Crohn's or colitis? Crohn’s and Colitis Canada currently promotes studies conducted by scientists affiliated with academic institutions who have demonstrated proof of ethics approval. Promotion will be via our website or social media accounts (Twitter, Instagram, Facebook, and LinkedIn). At this time, we cannot promote research study recruitment via email. 

To submit a request to have your study promoted by Crohn's and Colitis Canada, complete the online form HERE. Our research programs team will review your request and connect with you about next steps.

Participate in Research icons

Active studies recruiting participants: 

  • Persons from across Canada are being invited to participate in the IMAGINE research study. The IMAGINE Network is investigating the interactions between inflammation, microbiome, diet and mental health in patient with IBD (Crohn’s disease or ulcerative colitis) or irritable bowel syndrome (IBS). IMAGINE is also studying whether new therapies (fecal transplants, diet, probiotics, cognitive behaviour therapy) have the potential to transform the management of IBD and IBS and their associated mental health issues.
    You may be eligible to participate in this study if you have been diagnosed by your physician with Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), including ulcerative colitis or Crohn’s disease, or are a healthy individual without gastrointestinal symptoms.

    Visit for more information and to find a recruitment site near you.
  • What is this study about?

    The Montreal Heart Institute is inviting you to participate in a study to evaluate the effects of a combination of antifungal drugs called terbinafine and itraconazole to treat Crohn Disease.

    The development of inflammation during Crohn's disease is linked to the presence of complex intestinal microorganisms, called microbiota.

    This microbiota can be composed of bacteria and fungi. These yeasts have the ability to adhere to the walls and cause a local immune reaction in the intestine causing inflammation.

    Terbinafine is a drug that has been used for many years to treat certain types of fungal infections of the skin and nails.

    Itraconazole is used to treat certain forms of fungal infections, both internal (inside the body) and external (on the skin). It exerts an action that prevents fungi from reproducing.

    The objective of the CD-IT study is to evaluate the response to the combination of two antifungals in patients with Crohn's disease who do not respond adequately to current therapy.

    This research project is approximately 28 weeks (7 months) in duration, divided into 6 visits plus a follow-up phone call. The treatment period is 20 weeks (5 months) using the combination of two antifungal drugs or placebos.

    Who can participate?
    • Adults between 18-65 years with active Crohn disease, with Harvey-Bradshaw Index (HBI) ≥ 5 to ≤ 16
    • Montreal area or Sherbrooke area
    This study has been approved by the Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal (REB# F1H-31333).

    Primary Contact
    Julie Fleury
    Principal Investigators
    Jean-Claude Tardif
    Montreal Heart Institute
    Edmond-Jean Bernard
    University of Montreal Health Centre (CHUM)
  • What is the study about?

    We are developing a transition program that aims to improve the process of transitioning to adult care for Inflammatory Bowel Disease (IBD) patients across Canada and internationally.

    What is involved?
    • Interviews with research team
    • Filling out questionnaires
    • Educational webinar
    • Taking part in the study can last about 36 months
    Are there benefits to participating?

    We want to learn if better transition will lead to better health.

    Who can apply?
    • Teens 16 - 17.5 years old
    • IBD diagnosis
    • Participation in this study is voluntary
    This study has been approved by the SickKids Research Ethics Board (REB# 1000078476).

    Primary Contact
    Claudia Tersigni

    Principal Investigator
    Eric Benchimol
    SickKids, CHEO, BCCH, McMaster
  • What is this study about?

    In this study we are testing a mobile application called LyfeMD. We want to see if using the LyfeMD app helps people improve their Inflammatory Bowel Disease, mental and physical health more than normal patient care.

    LyfeMD provides tailored lifestyle therapies such as nutrition, physical activity, and yoga-based therapies. Using these therapies does not change the other medical care you receive, like medication.

    There is NO COST to this study.

    Who can participate in this study?

    For this study we are looking for people with either Ulcerative colitis (UC) or Crohn’s disease (CD) in remission, who have a mobile phone, and are interested in tailored lifestyle therapies.

    This study has been approved by the University of Calgary's Conjoint Health Research Ethics Board (REB#20-1534_REN1).

    Primary Contact
    For more information, please reach out to:

    Research Coordinator: Munazza Yousuf
    Ph: 403-592-5231

    Principal Investiagtor
    Maitreyi Kothandaraman
    University of Calgary
  • The University of Calgary & the University of Alberta are inviting you to participate in a study that is using food to treat Crohn's disease.

    What is this study about?
    The purpose of this study is to see if the food you eat can improve your Crohn's flare. The study will also look at how different foods affect the bacteria in your gut.

    How can this study help you?
    We believe that what you eat matters.
    By changing your diet, you have the power to:
        • improve your nutrition status
        • lower inflammation
        • change your gut microbiome
        • improve your Crohn’s symptoms

    What are the benefits?
        • You will receive an eating plan made for you that may help you feel better.
        • You will get support from a dietitian at no cost to you.
        • This study will help us decide if all patients with Crohn's should get an eating plan designed just for them.
    Who can participate in this study?
    We are looking for people who are:
        • over 18 years of age
        • in a mild to moderate Crohn’s flare
        • on a stable dose of Crohn’s medications in the last 4 weeks (not including steroids)

    There are other criteria that we will look at, once we know you meet these basic ones.

    This study has been approved by the University of Calgary's Conjoint Health Research Ethics Board and the University of Alberta's Health Research Ethics Board - Biomedical Panel (REB#19-0402_MOD5).

    Primary Contacts
    For participation in EDMONTON, please contact:

    Ph: 780-492-0019

    For participating in CALGARY, please contact:

    Ph: 403-592-5231

    Principal Investigators
    Maitreyi Kothandaraman
    University of Calgary

    Christopher Ma
    University of Calgary

    Kathy McCoy
    University of Calgary

  • The ACED Job Demands and Accommodation Planning Tool (JDAPT) is aimed at helping people think about their support needs at work when they are living with a chronic health condition that can cause challenges, either occasionally or all of the time. The JDAPT asks about health-related difficulties with a range of job demands. It then provides the user with a personalized list of potential work supports and accommodation ideas.

    We want to learn whether the tool is helpful to people who are looking for support in managing their chronic, episodic health condition.

    We need your help!

    If you are currently resident in Canada and:
    • living with a chronic health condition or disability
    • in paid employment for 20 or more hours a week, and are
    • interested in learning about and using different types of work supports or accommodations,
    We invite you to take part in the JDAPT pilot evaluation study to help us understand whether the tool is helpful for people who are looking for support for support at work to help manage their chronic, episodic health condition.

    What's involved:
    • Completing an online questionnaire about you, your work, and your health
    • Using the JDAPT and responding to some questions about the tool
    • Completing two follow-up questionnaires – one three months after using the JDAPT and another questionnaire nine months later to help us learn about your use of the tool
    To thank you for your time, participants will receive a total of $100 in three installments. You will receive a $30 honorarium after completing the first questionnaire and the JDAPT. You will receive $35 for each of the two follow-up questionnaires.

    Please click here to learn more or join the study:

    This study has been approved by the University of Toronto's Research and Innovation Research Ethics Board (REB#41940)

    If you have questions about the study, please contact the ACED Study team at the Institute for Work & Health by email at

    Principal Investigator
    Monique Gignac
    Institue for Work & Health
  • For adults with IBD on home parenteral nutrition: Psychological factors and wellbeing, quality of life and line care. Join a survey study!

    Researchers at Cardiff University, Wales are examining psychological factors that may be associated with wellbeing, quality of life and line care amongst people who receive home parenteral nutrition (HPN). It is hoped that this study will help us understand more about the impact of these psychological factors, and in doing so, better understand what kind of support might benefit the mental wellbeing of people receiving HPN.

    Who can participate? We are inviting individuals who are 18 years or older with IBD and currently on home parenteral nutrition (HPN) to participate in an international, online survey.

    What will it involve? If you would like to take part, this will involve answering some questions that ask about your thoughts, feelings, behaviours and experiences. There will also be some questions asking you about your line care and whether you have had any line infections. The survey should take no longer than approximately 20-25 minutes.

    We would like to thank you in advance for your participation. Your responses are highly valued and will help us to understand more about what contributes to people’s wellbeing, quality of life and line care behaviours when receiving HPN.

    To complete the survey, please click the link:

    Please note that no personal identifiable information will be collected, and therefore responses are anonymous. All responses will be reported as part of a total data set, not individually.

    Principal Investigator:
    Sara Rea
    Cardiff University (Wales)
  • The PediCRaFT (Pediatric CRohn’s Disease Fecal Microbiota Transplant) Trial is the first Health Canada approved fecal microbiota transplant (FMT) trial for children living with Crohn’s disease across Canada.

    Study involves:
    i) Colonoscopy (optional): Patients will have baseline disease severity assessed on endoscopy, and receive FMT infusion into the terminal ileum via colonoscopy. Initial baseline colonoscopy (supervised by pediatric anesthesia, endoscopy nurse, and pediatric gastroenterologist) through McMaster Children’s Hospital’s outpatient pediatric endoscopy suite..

    ii) Rectal enema (optional): Patients may receive a rectal enema FMT infusion instead of colonoscopy, based on availability and patient preference. This is done through the McMaster Children’s Hospital outpatient Pediatric Gastroenterology & Nutrition clinic.

    iii) Oral FMT Capsule (6 weeks): Twice per week, for 6 weeks, you will be given oral capsules that you may take at home. Capsules will contain healthy bacteria. 

    Who is eligible?
    Children ages 3 to 17 years old, diagnosed with Crohn’s disease or IBD-U. 

    Study Requirements:
    1.) Bloodwork
    2.) Urine Samples
    3.) Stool samples
    4.) Complete a 6-Question survey

    This study has been approved by the Hamilton Integrated Research Ethics Board (REB#4457)

    To find out more information please get in touch with:

    Research Contact: Lee Hill
    Telephone: 514-443-8488

    Principal Investigator: Dr Nikhil Pai

  • The purpose of this study is to better understand the monitoring experiences, enablers and barriers, benefits and drawbacks, and preferences in adults with Crohn’s Disease. There is little information about patient perspectives and beliefs regarding disease monitoring and gathering this information can help to guide health care. Such an understanding will help to develop both communication strategies for patients to enhance understanding of rationale and best structure measurement of disease activity to optimize adherence and patient acceptance. We will gather information about your experiences and preferences during Crohn’s disease monitoring using online focus groups. Focus groups allow for 6-8 people to come together to share their knowledge and expertise in a confidential group format.

    Who can participate?
    • Are diagnosed with Crohn’s Disease;
    • Are 18 years of age or older;
    • Live in Canada, United States, Australia, United Kingdom [England, Scotland, Wales];
    • Speak and understand English fluently; and
    • Have experienced at least 2 types of disease monitoring [endoscopy (ex. colonoscopy), magnetic resonance enterography (MRE), CT scan, intestinal ultrasound, blood tests, or stool tests].
    Primary contact
    Toyin Ogunyannwo

    Principal Investigator
    Dr. Kerri Novak

  • Canada has among the highest incidence rates of Crohn's and colitis in the world.
  • 1 in 140 Canadians lives with Crohn’s or colitis.
  • Families new to Canada are developing these diseases for the first time.
  • Incidence of Crohn’s in Canadian kids under 10 has doubled since 1995.
  • People are most commonly diagnosed before age 30.

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