Primary Sclerosing Cholangitis (PSC)

This IBD clinical care pathway is a tool providing healthcare providers direction regarding the screening, management and follow-up for patients with primary sclerosing cholangitis (PSC).

Download the PDF

An interactive version of this pathway is currently in development and will be available soon.

Dr. Aldo J. Montano-Loza (University of Alberta) and Dr. Alex Frolkis (University of Calgary) are the leads for this clinical care pathway, including regular review and maintenance.

Last reviewed and updated in November 2025.

Disclaimer
Clinical care pathways are not a substitute for the personalized judgement and care of a trained healthcare professional.

Additional resources

For people with IBD
PSC Partners Canada: https://pscpartners.ca/resource/lessons-learned-post-liver-transplant/ (Link)

For IBD providers
EASL Clinical Practice Guidelines on sclerosing cholangitis: https://www.journal-of-hepatology.eu/article/S0168-8278(22)00326-9/fulltext (Link)

Quick FactFaits en bref

Canada has among the highest incidence rates of Crohn's and colitis in the world.
1 in 140 Canadians lives with Crohn’s or colitis.
Families new to Canada are developing these diseases for the first time.
Incidence of Crohn’s in Canadian kids under 10 has doubled since 1995.
People are most commonly diagnosed before age 30.

Inflammatory Bowel Disease Clinical Care Pathways