Discovering Novel Treatments

The human gut contains a protein receptor called LGR5. LGR5 supports the healing and renewal of the gut lining after resurgence of disease in IBD patients. Despite it’s significant benefits, there have only been a handful of studies exploring the mechanism of LGR5. Recent studies have found that manipulation of the LGR5 may lead to novel treatments for IBD.
Dr. Gendron’s team aim to prove their hypotheses that the human gut contains new LGR5 which can be altered and lead to remission of IBD.
 

One of the main causes of Crohn’s Disease is poor control of microbes in the intestinal lining. Previous research has shown that the lack of a genetic factor that allows the body’s cells to detect molecules produced by bacteria can increase the risk of Crohn’s Disease.
Dr. Girardin and his team aim to better understand how the intestinal lining senses and controls microbes. Specifically, they will be studying at the role of two proteins in the intestinal lining that are responsible for protecting the intestine from harmful bacteria. The outcome of this study would help in designing novel strategies against Crohn’s Disease.