Inflammatory Bowel Disease Clinical Care Pathways

Initiation of Immunomodulators

This IBD clinical care pathway provides a guideline for health care providers when initiating immunomodulators (thiopurines and methotrexate) and its use in adults with inflammatory bowel disease.

Use the Pathway

Download the PDF

Disclaimer: Clinical care pathways are not a substitute for the personalized judgement and care of a trained healthcare professional. 

Clare McCabe Woodrow (Alberta Health Services) and Dr. Natasha Bollegala (Women’s College Hospital & University of Toronto) led the review and update for the current version of this IBD Clinical Care Pathway.

Additional resources

For IBD providers

• Harvey Bradshaw Index 
• Partial Mayo Scoring Index
• Therapy decision tree for Crohn’s disease
• Therapy decision tree for ulcerative colitis

For people with IBD

• Azathioprine or 6-Mercaptopurine (6-MP) for IBD
• Taking Azathioprine 
• Taking 6-Mercaptopurine (6-MP) 
• Methotrexate information sheet
  • Methotrexate for IBD 
  • Taking Methotrexate

Please provide us with feedback! 

If you have used this clinical care pathway, please take a moment to fill out this survey to provide your valuable feedback!