Patients with inflammatory bowel disease (IBD) report a variety of food intolerances. However, the main dietary triggers and pathways involved are unknown. Certain foods such as wheat and dairy that are not properly digested by our enzymes may cause adverse effects. Although our gut microbiota may help in the digestion, IBD patients often present an altered microbiota, which may include the loss of beneficial microbes.
Dr. Caminero’s study aims to broaden our understanding of whether the microbes hosted in the guts of IBD patients have a reduced digestive capacity against certain types of foods thus causing adverse effects. The study will also look into the effects of different dietary components in animal models of colitis.
The findings of this study will help guide dietary advice in clinical practice; in particular, it will pave the way for novel preventive and therapeutic approaches using probiotics in IBD patients with specific food intolerances.