Helping Manage Symptoms
Living with Crohn’s disease or ulcerative colitis often means dealing with pain, weight loss, fatigue, anemia or diarrhea.
With the support of grants from Crohn's and Colitis Canada, the researchers noted below are conducting research projects that focus on developing a better understanding of these symptoms with the goal of discovering novel treatments that will reduce or even eliminate symptoms altogether.
2018 Grant Recipients
Dr. Charles Bernstein | University of Manitoba
Research: Brain imaging in depression, anxiety, and fatigue in IBD
Dr. Bernstein’s research seeks to expand our understanding of the relationship and interactions between the brain and gut. Researchers know people living with IBD experience higher rates of depression and anxiety disorders compared to the general population. Yet, they do not fully understand how these mental health issues impact a patient’s symptoms. Using novel brain scanning techniques, Dr. Bernstein hopes to use this new information to improve how IBD is treated.
Dr. Prévost Jantchou | CHU Sainte-Justine
Research: Vitamin D for prevention of Crohn’s disease relapses in children
Dr. Jantchou believes his research can help reduce the potential for relapse, improve care, and ultimately enhance the overall quality of life for children living with Crohn’s disease. Given the higher prevalence of Crohn’s disease in northern countries, his research will examine the environmental factors that may be at play for Crohn’s disease patients. Dr. Jantchou will compare the effect of a high dose of vitamin D with a standard dose as an adjunct therapy for Crohn’s disease.
2017 Grant Recipients
Dr. Deanna Gibson | University of British Columbia
Co-investigators: Dr. Sundeep Sing, Dr. Kevan Jacobson, and Dr. Natasha Haskey
Research: The Mediterranean diet pattern reduces colitis
Many patients with inflammatory bowel disease (IBD) believe that diet impacts their symptoms and disease, but evidenced-based nutrition guidelines are lacking. Although patients blog about diet and many on-line sources of information state that certain diets can improve or exacerbate symptoms, few research studies have found a single dietary factor as being protective or harmful for IBD. Novel dietary approaches for the prevention and management of IBD are urgently needed, so health professionals can provide patients with sound nutrition guidance.
Fats are essential nutrients to health and must be consumed for normal development and survival. Different types of fats have different effects on the body. Dietary fat can impact the inflammation in our intestine, however the role of different types of fats and their impact on IBD remains unclear. Understanding the effects of fat in IBD is important since fat restriction in a patient with IBD could be harmful to their health and nutritional status.
This proposal will examine the effects of dietary fats on colitis both in isolation from each other and in combination as seen in the Mediterranean diet pattern. The Mediterranean diet pattern is widely suggested as an ‘anti-inflammatory’ diet and these properties are believed to be derived from the fat content of the diet. Dr. Gibson’s research shows that monounsaturated and saturated fats combined with fish oil are beneficial in mice with experimental colitis. She will examine the effect of this diet in patients with ulcerative colitis.
2016 Grant Recipients
Dr. Stephen Vanner | Queen’s University
Co-investigators: Dr. Katrina Gee, Dr. David Reed, and Dr. Alan Lomax
Research: Turning off the ‘Switch’: Preserving the Analgesic Actions of the Endogenous Opioid Pathway in IBD
Pain is a debilitating symptom for many with IBD. Dr. Vanner is studying how the abdominal pain seen in IBD is caused and whether there are more effective ways to treat it. Ultimately, this work may lead to better management of pain medications.